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Micro lecture 5 chapter 18 (Autoimmune Diseases (most appear at random and…
Micro lecture 5 chapter 18
graft versus host disease
doctors will use bone marrow allowgrafts as part of the treatment for leukemia's and lymphoma
what can happen at times is that donated bone marrow T cells regard the pts cells as foreign
so an immune response begins and you get a draft verse host disease
if the donor recipient differ in MHC class I molecules
Donor recipient matching and tissue typing
MHC compatibility between donor and recipientis difficult due to a hihg degree of variablility
A family member not always available such as event when you need a heart
Type Iv hypersensitivity
Actions of immunosuppressive drugs
important classes of immunosuppressive drugs
glucortocoids
cytoxic drugs
cyclosproine
lymphocyte depleting therapies
Glucocorticoids
sometimes called corticouds and commonly called steroids
prednisoneis a common one
Cytoxic Drugs
Stop mitosis and cytokenesis
cyclophosphamide
azathioprine
Cyclosporine
polypeptide that comes from fungi prevents the making of interleukins and interferons by T cells
whichends up blocking Th1 responses
usually used in combination with glucocorticoids
Lymphocyte depleting therapies
type of therapy attempts to reduce the many adverse side effects association with immunisuppressive drugs
one technique was administeringand antiserum called anti-lymphocyte globulin
Autoimmune Diseases
most appear at random and spontaneous
scientists have noted common features
occur in men more than women
more common in elderly
may result when an individual begins to make antibodies or cytoxic T cells against normal body cells