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Cellulitis (Cultures? (Aspirate & gram stain (Susceptibility tests),…

- - - - Especially for injection drug users
- - - - No MRSA
        
        PCN VK PO
        
        Clindamycin
        
        For PCN allergy
        
        Cephalexin
        
        Dicloxacillin
        
        For Pencillin-resistance
      - MRSA
        
        TMP/SMX OR doxycycline
        
        PLUS amoxicillin, PCN, OR cephalexin
      - PO therapy, 5 days
    - - Systemic evidence
      - No MRSA
        
        PCN, cefaxolin, ceftriaxone, OR clindamycin
      - MRSA
        
        Vanc, dapto, OR linezolid
      - IV therapy, 5 days
    - - Necrotizing
        
        Vanc OR Linezolid
        
        PLUS pip/tazo, imipenem/cilastatin, ertapenem, OR meropenem
        
        PLUS cetriaxone-metronidazole
        
        IV x1-2w
      - If no suspicion of necrotizing fascitis
        
        Vanc
        
        PLUS pip/tazo, imipenem/cilastatin, OR meropenem
        
        IV x5 days
  - - - Drain, no abx
    - - Drain, PO abx
        
        TMP/SMX OR doxycycline
    - - Drain, IV abx
        
        Vanc, dapto, linezolid, OR ceftriaxone