Please enable JavaScript.
Coggle requires JavaScript to display documents.
Mental Health Pharmacology (Mostly depression (NRIs: Reboxetine,…
Mental Health Pharmacology
Benzos (loraze/temaze-pam)
Results in sedative, hypnotic, anxiolytic and anti-convulsant effect.
CYP450 metabolism.
Act on GABAa receptor to enhance inhibition
TCAs (Amitriptyline, clomipramine)
Antagonists to a variety of other receptors.
Act as SNRIs- Block serotonin and norepinephrine transporters therefore increasing levels.
Atypical vs Typical- .
Atypical
Risperidone
Quetiapine
Olanzapine
Amisulpride
1st line in Schizo
.
Serotonergic
,
More likely metabolic syndrome
Arapiprazole
Clozapine: Hypersalivation + agranulocytosis
MoA:
5HT2a:
D2 Receptor antagonism
Methylphenidate: Dopamine and NRI
Typical
(1st Gen)
Sulpride
Flupentixol
Chlorpromazine
Haloperidol- Prolonged Q-T interval
All work on D2/3 receptors to reduce transmission.
More EPSEs
,
less tolerable, lower efficacy for depressive and cognitive
Side Effects
Anti-muscarinic: See, wee, spit + shit
Anti-histaminergic: Sedation + weight gain
Anti-adrenergic: Postural hypotension, tachycardia.
Endocrine: Prolactin, bone density, glucose tolerance.
P: arkinsonism, A: kathisia: Restlessness D: Dystonia : TD (tardive dyskinesia)
Mostly depression
NRIs: Reboxetine, melthylphenidate (D2 also)
SNRI: Venlafaxine, duloxetine, Atomoxetine
SARIs:Trazodone
SSRI: Citalopram, fluoxetine, sertraline
Presynaptic alpha2-adrenoreceptor blocker (Mirtazapine)
MAOIs
Phenelzine, moclobemide (RIMA)
Major depressive, social anxiety
Alcohol withdrawal: Chlordiazepoxide. Maintenance: Naltrexone
Anti-convulsant/mood stabilisers
Carbamazepine
Lamotrigine
Na valproate