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Gout (Pseudogout (Tx (Acute management similar to regular gout, Chronic:…

- - - - Inflammation, pain, warmth, swelling
  - - - Diuretics, ethanol, ethambutol, nicotinic acid, ASA <2g/day, cyclosporine, cytotoxic drugs, levodopa
- - - - Dual therapy
    - - First-line: allopurinol
        
        PLUS anti-inflam: low dose colchicine & low dose NSAID
      - Second-line: febuxostat or probenecid
        
        PLUS steroids-- low dose pred
      - If target is not achieved, titrate to max dose
    - - Nonpharm
        
        Diet changes, med changes, weight loss
        
        Niacin, thiazides, calcineurin inhibitors
    - - EULAR-- 1st dx <40yo; serum uric acid >8; high risk comorbidity (HTN, IHD, HF)
  - - - NSAIDs
      - Colchicine
    - - Dual therapy of..
        
        NSAID
        
        Colchicine
        
        Corticosteroid
        
        PO
        
        IA
        
        Inadequate response --> IL-1 inhibitor