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Cirrhosis (Clinical Presentation (Xanthelasma - yellow fat deposits under…
Cirrhosis
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Diagnosis
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Imaging
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Ultrasound
May be marginal modularity of the liver surface and distortion of the arterial vascular architecture
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Treatment
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Patients should undergo 6 mostly ultrasound screening for early development of hepatocellular carcinoma
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Pathophysiology
Chronic liver injury results in inflammation, matrix deposition, necrosis and angiogenesis of all which lead to FIBROSIS
Liver injury causes necrosis and apoptosis, releasing cell contents and reactive oxygen species (ROS)
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The characteristic features of cirrhosis are regenerating nodules separated by fibrous septa and loss of lobular architecture within the nodules
Two types
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Macronodular cirrhosis
They are nodules of varying size and normal acini (functioning unit of the liver) may be seen within the larger nodules
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Complications
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Coagulopathy; fall in clotting factors II, VII, IX & X
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Not a specific disease; it is an end stage of all progressive chronic liver diseases; which once fully developed is irreversible and may be associated clinically with symptoms and signs of liver failure and portal hypertension
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Histologically, there is loss of normal hepatic architecture with bridging fibrosis and nodular regeneration
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