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Chronic Pancreatitis (Main Causes (Hereditary (Defects in the…
Chronic Pancreatitis
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Pathophysiology
Abnormalities of bicarbonate excretion can be the result of functional defects at the level of the cellular wall
Increased intrapancreatic enzyme activity leads to the precipitation of proteins within the duct lumen in the form of plugs
Obstruction or reduction in bicarbonate secretion, which produces an alkaline pH which in turn stabilises trypsinogen, leads to the activation of trypsinogen as pH rises making it more unstable and causing its activation into trypsin which leads to pancreatic tissue necrosis
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Diagnosis
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Serum amylase and lipase
May be elevated, but in advanced diseases, there may not be sufficient residual acinar cells to produce elevation
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Differential Diagnosis
Pancreatic malignancy
Lots of common symptoms should be thought of especially when there is a short history and pancreatic mass
Debilitating continuing inflammatory process of the pancreas resulting in progressive loss of exocrine pancreatic tissue which is replaced with fibrosis