Please enable JavaScript.
Coggle requires JavaScript to display documents.
Immune disorders: Lecture 4 (Systemic Lupus Erythematosus (erythematosus,…
Immune disorders: Lecture 4
Systemic Lupus Erythematosus
pts make auto-antibodies against normal organs and tissues
end up with different lesions and clinical manifestations that make it hard to diagnose
self reacting antibodies against nucleic acids are constant
can have two types
easy to misdiagnose
systemic
affects whole body
lupus
wolf
erythematosus
redness of the skin
caused by deposits of nucleic acid antibody complex in skin
sun makes worse
triggers are said to be drugs
treat with immunosuppressive drugs and/ or corticosteroids to reduce autoantibody function and inflammation
Type 4 hypersensitivity
type that when encounter allergens you are sensitized and have a delayed reaction
results from interaction with antigen or its cells or T cells
have two common types
TB response
exposed skin reacts to an injection of TB bacteria under the skin
used to diagnose contact with antigen of disease
when injected into a healthy person with no vaccine or isn't infected there should be no response
if response is red, swelling, hard, and 10 ml or more it can be positive and in people who have been immunized, currently infected, or have been previously infected
the response is based on memory T cells and slowly progresses
Allergic Contact Dermatitis
oil poison ivy or oak have an oil that is small and sensitive for us to experience when it binds to any protein it contacts
our body looks at the chemically modified skin proteins as foreign so it builds a intensely irritating rash, immune response
severe: develop acellular, fluid-filled blisters
can be caused by formaldehyde, cosmetics, dyes, drugs, metal ions, or latex
Treat: corticosteroids or if severe with epinephrine
Good to wash area that has contacted the allergen with soap and water