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Neonatal Jaundice (before 3 months of life (first 2 weeks of life…
Neonatal Jaundice
before 3 months of life
first 2 weeks of life
physiological jaundice
pathological
unconjugated hyperbilirubinemia
increase bilirubin production
hemolysis
ABO, Rh incompatibility
others
extravasation of blood
polycythemia
decrease uptake of bilirubin in liver
cardiac failure
congenital portosystemic shunt
decrease conjugation
prematurity
breastmilk jaundice
metabolic
hypothyroidism
IEM
infections
increase enterohepatic circulation
breastfeeding jaundice
pyloric stenosis
intestinal obstruction
ileus
conjugated hyperbilirubinemia
decreased bilirubin excretion
biliary obstruction
extrahepatic
intraluminal obstruction
biliary tree abnormalities
extraluminal obstruction
intrahepatic
hepatocellular dysfunction
hepatitis
toxin
IEM
autoimmune
beyond first 2 weeks of life
after 3 months of life
unconjugated hyperbilirubinemia
increased hemolysis
RBC membranopathies
RBC enzyme deficiences
hemoglobinopathies
autoimmune hemolytic anemia
infection
drug induced
impaired conjugation
conjugated hyperbilirubinemia
biliary obstruction
hepatocellular dysfunction