micro-18 lect-3
type II
results when cells are destroyed by an immune response
a component of many autoimmune disease
ABO system and tranfusion reactions
RBCs have many diff glycoproteins and glycolipid molecules on its surface
there are several sets of blood group antigens
some surface molecules will have different function slike transporting glucose and ions across the membrane
if the recipient has preexistin antibodies to foreign blood group antigens
hemolysis releases hemoglobin in bloodstream, which could cause kidney damage
Rh system
rh antigen-
common to RBC of humans and rhesus monkeys
this antigen transports anions and glucose across the cell membrane
about 85% of women are Rh+ and 15% are Rh-
normally the placent keeps the fetal RBC seperate from the mothers blood
at first, IgM antibodies are being made which are too big to pass the placenta so no problems arise during the 1st pregnancy
Type III
Hypersensitvities can affect the lungs causing a form of pneumonia, kidneys, lupus and RA
people become sensitized when minutemild spores or other antigens are inhaled deep into the lungs which stimulate the making of antibodies
can cause localized reactions
farmers lung, igeons lung, mushroom growers lung, and libraians lung
Glomerulonephritis
occurs when immune complexes circulating in blood are deposited in the walls of the glomeruli
these immune complexes damage the glomerular cells, which lead to increased cytokines that trigger cells to make more of tbe proteins that underlie the cells decreasing or impeding blood formation
RA
immune system attacks its own bodys antigens
immune complexes deposited in the joint
trigger not well understood only found in humans
follows an infectous disease in genetically susceptible people
treated with antiinflammatory drugs and immunosuppressive drugs to stop the antibody immune response