micro-18 lect-3

type II

results when cells are destroyed by an immune response

a component of many autoimmune disease

ABO system and tranfusion reactions

RBCs have many diff glycoproteins and glycolipid molecules on its surface

there are several sets of blood group antigens

some surface molecules will have different function slike transporting glucose and ions across the membrane

if the recipient has preexistin antibodies to foreign blood group antigens

hemolysis releases hemoglobin in bloodstream, which could cause kidney damage

Rh system

rh antigen-

common to RBC of humans and rhesus monkeys

this antigen transports anions and glucose across the cell membrane

about 85% of women are Rh+ and 15% are Rh-

normally the placent keeps the fetal RBC seperate from the mothers blood

at first, IgM antibodies are being made which are too big to pass the placenta so no problems arise during the 1st pregnancy

Type III

Hypersensitvities can affect the lungs causing a form of pneumonia, kidneys, lupus and RA

people become sensitized when minutemild spores or other antigens are inhaled deep into the lungs which stimulate the making of antibodies

can cause localized reactions

farmers lung, igeons lung, mushroom growers lung, and libraians lung

Glomerulonephritis

occurs when immune complexes circulating in blood are deposited in the walls of the glomeruli

these immune complexes damage the glomerular cells, which lead to increased cytokines that trigger cells to make more of tbe proteins that underlie the cells decreasing or impeding blood formation

RA

immune system attacks its own bodys antigens

immune complexes deposited in the joint

trigger not well understood only found in humans

follows an infectous disease in genetically susceptible people

treated with antiinflammatory drugs and immunosuppressive drugs to stop the antibody immune response