Please enable JavaScript.
Coggle requires JavaScript to display documents.
Conn's Syndrome (Diagnosis (Hypokalaemic ECG
Flat T waves
ST…
Conn's Syndrome
Diagnosis
Hypokalaemic ECG
- Flat T waves
- ST depression
- Long QT
-
Plasma aldosterone: renin ratio (ARR)
- Initial screening test
- Spirolactone and epiereone should be stopped 6 weeks before test
- Aldosterone is much higher - NOT DIAGNOSTIC, used mainly for screening
-
-
Key Facts
Primary hyperaldosteronism - excess production of aldosterone, independent of the renin-angiotensin system
- Results in increased sodium and thus water retention (resulting in increased BP) and decreased renin release
- K loss
- Combination of hypokalaemia and hypertension
-
Symptoms
-
Hypertension
- Due to an increase in blood volume
- Can be severe and is associated with renal, cardiac and retinal change
- May not always be present
Hypokalaemia
- Weakness/cramps
- Paraesthesia
- Polyuria
- Polydipsia
-
-
-
-
Pathophysiology
Disorder of the adrenal cortex characterised by excess aldosterone production leading to Na and water retention and K loss, and the combination of hypokalaemia and hypertension due to aldosterone producing carcinoma
Differential Diagnosis
Must be differentiated from secondary hyperaldosteronsim which arises when there is EXCESS RENIN which stimulates aldosterone release
-