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Chapter 18 Lecture 4 (Type III (Immune Complex Mediated) Hypersensitivity,…
Chapter 18 Lecture 4
Type III (Immune Complex Mediated) Hypersensitivity
systemic lupus erythematous
patient makes antibodies against numerous self-antigens found in normal organs and tissues
1 consistent feature is development of self reactive antibodies against nucleic acids
many different lesions mean many different manifestations
bleeding disorders, hemolytic anemia, muscle inflammation
rash caused by deposit of nucleic acids in the skin
Type IV (Delayed Cell Mediated) Hypersensitivity
Inflammatory response 12-24 hours after contact
results from interactions with antigens
delay reflect time it takes for macrophages and T cells to migrate and divide at site of antigen
Tuberculin response and allergic contact dermatitis
interactions between body tissue and grafted tissue
Tuberculin Response
skin exposed to TB under skin with an injection
Mantoux used to Dx
healthy - no response
exposure: red, hard, greater than 10mm, and swelling
response facilitated by memory T cells that cause slowly developing inflammation
Allergic Contact Dermatitis
oil of poison ivy - small molecule that becomes antigenic when binds to almost any protein, including ones on our skin
our body looks at chemicals modified skin proteins as foreign which leads to skin irritation
severe cases - acellular fluid filled blisters develoiped caused by formeldehyde, cosmetics, dyes, drugs, metal ions, latex