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Fidarestat (decreased (Cox-2,, iNOS (HT 29 with high glucose), dox adverse…
Fidarestat
decreased
PCNA,
HFD mice
β-catenin
phospho-NF-κB
the number of polyps
Cox-2,
iNOS
HT 29 with high glucose
NFκB
AKT
PKC B2
AOM mice
XIAP
survivin
Keap-1
mTOR
BAX
pro apoptotic
MDR1,
MRP1,
ABCG2
dox adverse effects
induction of troponin-I and other inflammatory molecules in serum and heart
endothelial cell death induced
expression of ICAM-1 and VCAM-1
angiogenesis factors
ki67
invasion and migration
MMP2 and MMP9 as well as ICAM, VCAM
increased
PKC B2
HFD
Nrf2
Nrf-2 DNA binding activity
oxidative stresss
PCG-1α,
Nrf1,
mitochondrial biogenesis
TFAM
AMPK
p53
DR5
TRAIL-induced cytotoxicity
apoptosis
DR4
Bcl-xL,
cell survival
Bcl-2
survivin,
XIAP,
FLIP
cytochrome c
caspases-3
foxo3
AKT/PI3K
sensitivity to dox
negatively regulates
help adopt to
enhance
under
increasing
regulate