Please enable JavaScript.
Coggle requires JavaScript to display documents.
Week 8: Lipid Metabolism (Transportation of Lipid via blood ((involve) 5…
Week 8: Lipid Metabolism
Lipid Degradation & Absorption
(Degradation starts in) Small intestine
Lipase Break down triglycerides into simpler lipids.
with bile salts: Amphipathic & made from cholesterol in the liver
The hydrophobic part of the bile salt surrounds the lipids
(Absorption starts) lipid products can
cross intestine
Synthesis of triglyceride
Make phosphatidate (diacylglycerol 3-phosphate) with two acylation reaction from glycerol-3-phosphate
phosphatidate is hydrolyzed by a phosphatase to give diacylglycerol (DAG)
The DAG is acylated to triacylglycerol by diacylglycerol acyltransferase
Transportation of Lipid via blood
Transportation of Cholesterol
Cholesterol (from diet or made in body) is packaged into a Low density lipoprotein (LDL) complex.
(explanation) lipids go to tissues through the blood stream.
too hydrophobic to go themselves so they are escorted by APOLIPOPROTEINS.
SUCH PROTEINS bind the lipids and keep them soluble in the bloodstream.
Low density lipoprotein (LDL) molecule is bound by LDL receptors on cell surface through the APOLIPOPROTEIN B-100 component.
LDL receptor and molecule is internalized by cell membrane pits forming through
recruitment of clathrin proteins into CLATHRIN-COATED VESICLES.
CLATHRIN-COATED VESICLES fuse with ENDOSOMES and clathrin molecules
go back to cell surface.
Endosome containing LDL fuses with LYSOSOME, and then the APOLIPOPROTEIN
B-100 portion is degraded and cholesterol released within lysosome.
Cholesterol can either be converted to CHOLESTERYL ESTER by Acyl-CoA
Cholesterol Transferase (ACAT) OR go to the ENDOPLASMIC RETICULUM.
Increased levels of cholesterol in the endoplasmic reticulum signals the cells to make
2 more items...
(involve) 5 classes of lipoproteins
