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mtor 1 (activate P70S6K (ultimately pro and DNA synthesis), P, activats…
mtor 1
activate P70S6K
ultimately pro and DNA synthesis
P
activats HIF1a
inhibits autophagy
AAs
leucine
DNA damage
p53
inhibit
by phosphorylation
growth factors (insulin)
AKT
ARG
activate
RAG
ATP
Ras
AMP activates
AMPK
ATP could reduce AMPK and actvate mtor
activated during energy depletion
growth factors (insulin)
activate
mtor 2
Activate AKT
inhibit apoptosis
through foxo regulation
regulates glucose metabolism
PKC
cytoskeletal reorganization
sgk
iron transportaion
hypoxia
caspase 1-3
negatively regulate
GSK3
P70S6K