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Week 7: Protein Metabolism (Protein Turnover:balance of protein synthesis…
Week 7: Protein Metabolism
Protein Turnover:balance of protein synthesis and protein degradation :green_cross:
The body’s needs change constantly, therefore the types and level of proteins required also change constantly
(protein degradation)starts in the stomach
Cellular protein degradation also contribute to the amino acid pool
Degradation continues in the small intestines
Then Absorption
Involves 4 types of enzymes
Pepsin: nonspecific protease works well at pH 2
Carboxypeptidase digest proteins from the carboxyl-terminal end
Endopeptidase cuts internal peptide bonds, similar to pepsins
Aminopeptidase digest proteins from the amino-terminal end
3 Reasons
Damaged proteins
Proteins life span
Proteins with vital roles that must be turned off asap
Ubiquitin tags protein for destruction
Amino acids precursor of many biomolecules
:check:
3 roles
Purines and pyrimidines
Nitric oxide
Building blocks of protein and peptides
Removal of nitrogen atoms and fate of carbon atoms
:check:
Deamination: removal of an amino group from a molecule
happens in the liver
Carbon skeleton transform into metabolites that eventually converts into glucose or used by citric acid cycle
The 20 amino acids are converted into
7 types of intermediates of the Citric Acid Cycle
Biosynthesis of Amino acids
:check:
Nitrogen fixation:nitrogen gas is converted to ammonia by enzyme of certain bacteria
:check:
