Please enable JavaScript.
Coggle requires JavaScript to display documents.
Pernicious Anemia (Symptoms (decreased nerve stimulation (depression,…
Pernicious Anemia
Symptoms
skin/mucous membrane pallor
fatigue
shortness of breath
tachycardia
headaches
bodyaches
decreased nerve stimulation
depression
difficulty thinking
numbness/tingling
balance isssues
weakness
Risk Factors
seen in adults >60yrs old
present but not diagnosed till later years
Northern European descent
greater in females
history of chronic gastritis
H. Pylori
possible trigger for autoimmune reaction
Treatment
initial: weekly B-12 injections
chronic: monthly B-12 injections
not preferred
high oral doses of B-12
endoscopy screening
increased risk for GI cancer
blood products if needed
Diagnostic Findings
Hemoglobin <12gm/dL
evidence of B-12 deficiency
macroovalocytees
reticulocytopenia
hypersegmented granulocytes
bone marrow megaloblastosis
low B-12 levels
gastric mucosal atrophy
intrinsic factor antibodies
parietal cell antibodies
Vitamin B-12 Deficiency
missing intrinsic factor
protein that synthesizes B-12
destruction of parietal cells
destruction of zymogenic cells
body does not absorb/produce enough B-12
lack of B-12
fewer RBCs
fewer WBCs
fewer platelets
neural/brain deficiencies
autoimmune/ congenital disease in intestine
