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Innate Immunity: Lecture 5 (Compliment system (set of serum proteins…
Innate Immunity: Lecture 5
Compliment system
set of serum proteins designated numerically according to order of discovery
complement activation results in lysis of foreign cells
attracts phagocytes to site of infection
indirectly triggers inflammation and fever
3 ways to be activated
Classical Pathway
antibodies, in adaptive immunity, bind to foreign substances, called antigens
the binding begins a series of enzyme activities called complement cascade
named because the various proteins act to compliment with antibodies
Alternative Pathway
Activation occurs independently of antibodies with the cleavage of C3 into two fragments, C3a and C3b
will occur at a slow rate in plasma
C3b binds binds to microbial surfaces, and stabilizes long enough to work with three other plasma proteins (Factors B, D, P) to split more C3
useful in the early stages of infection
Lectin
Mannose sugar is found on surfaces of fungi, bacteria, and viruses
attaches to activate molecules that are called lectin
will begin a series of enzyme activities that lead to the compliment cascade