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Drugs
Methamphetamine: -Known as meth mimics dopamine
-It is taken into the cell by transporters forcing dopamine out and works in reverse overstimulating the cell
-It is highly addictive makes user feel intense pleasure adrenaline
-It is known as meth it can be smoked,injecting and snorting it is like a powder also it it is a stimulant. It has effects of speeding up nerve activity,seizures, alertness,over heating, energy, violent self harming behavior
Alcohol: -Inhibitory neurotransmitter GABA control neural activity glutamate
-When the alcohol enters it doubles the sedative as it makes the GABA more sedative as it binds to the glutmate receptors preventing from exciting cell
-Affects memory formation,decision making and impulse control
-It is ethanol,wine,beer,or liquor and it is done by drinking it is a depressant it can impair balance, speech,memory loss, shaking,headache
Marijuana: -It can be known as cannabis,edibles, and extracts.Can be smoked,vaping,swallow and it is from a plant based. It is a compounds.Can cause anxiety,paranoia, and slow reactions.
-Affects the inhibitory neurotransmitter they inhibit dopamine from being released. The canabinoid receptors are turned off the release of the inhibitory transmitter dopamine can't be released THC binds to the canabiniod receptors. Inhibition turned off dopamine squirts into synapse
Ecstasy: -Also known as MDMA can be taken swallowing or snorting it is a hallucinogenic it is a stimulant
-The effects are decrease in energy,involuntary jaw movement,muscle cramps,euphoria, sweating,chills,panic attack and seizures
LSD: -It interferes with serotonin neurons as it resembles serotonin
-It bids to the receptors there is two types as it can go the first one which excites or to the second one that inhibits it
-The effects are feeling of wakefulness and evoking a startle response to unexpected stimulus
-Can be taken swallowing, snorting,injecting,or smoking. It can cause increase in body temp,tripping out, distortion,hallucination,paranoia
Heroine: -It is an opiod that can be injected and is like a morphine that is a stimulant
-Drowsiness,nausea,itching, body aches, similar to flu, addiction,vomiting
-Inhibitory neurotransmitter is affected and inhibits dopamine from being released but operates shut in down
-Produces immediate feelings of sedation and well being acts as a pain killer
Cocaine:- Affects the dopamine neurotransmitters it removes the the dopamine from the synapse cleft
-The cocaine blocks transporters leaving dopamine trapped in synoptic cleft overstimulates cells
-Abusers are fidgety and unable to stay still
-Known as crack also done by snorting or injecting also smoking. It is from plant and it is a stimulant. It makes people alert,confidence,paranoia,stroke,heart atttack
12 Cranial Nerves
6 Abducens nerves: -Fibers from inferior pons enter orbits via superior orbital fissures
-Primarily a motor, innervating lateral rectus muscle
7 Facial nerves: -Fibers from pons travel through internal acoustic meatuses and emerge through stylomastoid foramina to lateral aspect of face
-Chief motor nerves of face with five major branches
-Motor functions include facial expression, parasympathetic impulses to lacrimal and salivary glands
-Sensory function (taste) from anterior two-thirds of tongue
4 Trochlear nerves:-Fibers from dorsal midbrain enter orbits via superior orbital fissures to innervate superior oblique muscle
-Primarily motor nerve that directs eyeball
8 Vestibulocochlear nerves: -Afferent fibers from hearing receptors (cochlear division) and equilibrium receptors (vestibular division) pass from inner ear through internal acoustic meatuses and enter brain stem at pons-medulla border
-Mostly sensory function; small motor component for adjustment of sensitivity of receptors
-Formerly auditory nerve
3 Oculormotor Nerves: -Fibers extend from ventral midbrain through superior orbital fissures to four of six extrinsic eye muscles
-Function in raising eyelid, directing eyeball, constricting iris (parasympathetic), and controlling lens shape
10 Vagus nerves: -Only cranial nerves that extend beyond head and neck region
-Fibers from medulla exit skull via jugular foramen
-Most motor fibers are parasympathetic fibers that help regulate activities of heart, lungs, and abdominal viscera
-Sensory fibers carry impulses from thoracic and abdominal viscera, baroreceptors, chemoreceptors, and taste buds of posterior tongue and pharynx
5 Trigeminal nerves: -Largest cranial nerves; fibers extend from pons to face
-Three divisions:Ophthalmic (V1) passes through superior orbital fissure,Maxillary (V2) passes through foramen rotundum,Mandibular (V3) passes through the foramen ovale
-Convey sensory impulses from various areas of face (V1 and V2)
-Supply motor fibers (V3) for mastication
9 Glossopharyngeal nerves: -Fibers from medulla leave skull via jugular foramen and run to throat
-Motor functions: innervate part of tongue and pharynx for swallowing and provide parasympathetic fibers to parotid salivary glands
-Sensory functions: fibers conduct taste and general sensory impulses from pharynx and posterior tongue, and impulses from carotid chemoreceptors and baroreceptors
2 Optic Nerves: -sensory nerve that involves vision
-Arise from retinas; really a brain tract
-Pass through optic canals, converge, and partially cross over at optic chiasma
-Optic tracts continue to thalamus, where they synapse
-Optic radiation fibers run to occipital (visual) cortex
-Purely sensory (visual) function
11 Accessory nerves: -Formed from ventral rootlets from C1 to C5 region of spinal cord (not brain)
-Rootlets pass into cranium via each foramen magnum
-Accessory nerves exit skull via jugular foramina to innervate trapezius and sternocleidomastoid muscles
-Formerly spinal accessory nerve
1 Olfactory Nerve:-The olfactory nerve transmits sensory information to your brain regarding smells that you encounter.
-When you inhale aromatic molecules, they dissolve in a moist lining at the roof of your nasal cavity, called the olfactory epithelium. This stimulates receptors that generate nerve impulses that move to your olfactory bulb. Your olfactory bulb is an oval-shaped structure that contains specialized groups of nerve cells.
-From the olfactory bulb, nerves pass into your olfactory tract, which is located below the frontal lobe of your brain. Nerve signals are then sent to areas of your brain concerned with memory and recognition of smells.
12 Hypoglossal nerves: -Fibers from medulla exit skull via hypoglossal canal
-Innervate extrinsic and intrinsic muscles of tongue that contribute to swallowing and speech
Spinal Nerves
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There is 31 pairs of spinal nerves: -8 pairs of cervical nerves (C1–C8)
-12 pairs of thoracic nerves (T1–T12)
-5 pairs of lumbar nerves (L1–L5)
-5 pairs of sacral nerves (S1–S5)
-1 pair of tiny coccygeal nerves (C0)
Reflex Arc
Components: 1.Receptor: site of stimulus action
2.Sensory neuron: transmits afferent impulses to CNS
3.Integration center: either monosynaptic or polysynaptic region within CNS
4.Motor neuron: conducts efferent impulses from integration center to effector organ
5.Effector: muscle fiber or gland cell that responds to efferent impulses by contracting or secreting
Classification: Somatic reflexes -Activate skeletal muscle
Autonomic (visceral) reflexes-Activate visceral effectors (smooth or cardiac muscle or glands)
Neurotransmitters
-Major neurotransmitters of ANS are acetylcholine (ACh) and norepinephrine (NE)
-Ach (same as ACh used by somatic motor neuron) is released by cholinergic fibers at: All ANS preganglionic axons and All parasympathetic postganglionic axons
-NE is released by adrenergic fibers at: Almost all sympathetic postganglionic axons, except those at sweat glands (release ACh)
Effects of neurotransmitter depends on whether it binds to cholinergic receptor or adrenergic receptor
Automic Nervous System
-Both have motor fibers but differ in:
-Target organ responses to neurotransmitters
-Efferent pathways and ganglia
-Effectors
Efferent Pathways and Ganglia
-ANS innervates cardiac muscle, smooth muscle, and glands
ANS: pathway uses a two-neuron chain
-1)Preganglionic neuron: cell body in CNS with thin, lightly myelinated preganglionic axon extending to ganglion
-2)Postganglionic (ganglionic) neuron (outside CNS): cell body synapses with preganglionic axon in autonomic ganglion with nonmyelinated postganglionic axon that extends to effector organ
-Automatic nervous system (ANS) consists of motor neurons that: Innervate smooth muscles, cardiac muscle, and glands and Make adjustments to ensure optimal support for body activities (Shunts blood to areas that need it and adjusts heart rate, blood pressure, digestive processes, etc.
-Operate via subconscious control
-Also called involuntary nervous system or general visceral motor system
ANS effects
-Preganglionic fibers release ACh
-Postganglionic fibers release norepinephrine or ACh at effectors
-Effect is either stimulatory or inhibitory, depending on type of receptors
Divisions of Autonomic Nervous System
-Two arms of ANS: 1)Parasympathetic division: promotes maintenance functions, conserves energy
2)Sympathetic division: mobilizes body during activity
-Dual innervation: all visceral organs are served by both divisions, but these divisions cause opposite effects
(Dynamic antagonism between two divisions maintains homeostasis