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Chapter 15 Lecture 4 (Nonphagocytic killing (phagocytosis kills pathogens,…
Chapter 15 Lecture 4
Nonphagocytic killing
phagocytosis kills pathogens
body can kill without phagocytes
kills by eosinophils
secretes antimicrobial chemical against pathogens too large to ingest
attack helminthes by adhering to surl
first evidence that DNA can have antimicrobial activity
nonspecific chemical defenses against pathogens
lysozyme
defensins
toll like receptors
nod proteins
interferons
complement
Natural Killer Cells
defensive leukocyte of innate immunity
secreting toxins onto surface of viral infection
nk cells can differentiate normal body cells because of mucous membrane
killing by neutrophils
can destroy microbes without phagocytosis
enzymes in cytoplasmic membrane add electrons to oxygen creating a superoxide radical
nitric acid brings on inflammation
Toll like receptors
integral membrane proteins produced by phagocytic cells
10 TLR total