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Luis Carrillo-Reid - optical control of neuronal ensembles (creating new…
Luis Carrillo-Reid - optical control of neuronal ensembles
manipulating behaviour with a single cell resolution
teaching martial art in seconds
cell assemblies
how to study?
optically
imaging 940 nm GCaMP6s
Optogenetics 1064
cool videos
visual stimularions
same analyses as santa cruse work
creating new assemblies/ensembles
with optogentics
pattern completion - only activating a single cell to get the whole patern back
just strengthening connections that were already there
how do you create new connections so?
didnt change what was already there
training
manipulating the ensembles
go and no go ensembles
single cell will recreat the ensemble
animal will lick
manipulate behaviour with a single cell
he can change the perseption of the animal
targeting cells that are not normally involved in the ensemble messes up the behavour
animal fails at the task
miniscope with single cell stimulation resolution