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Chapter 15 Lecture 4 (Nonspecific Chemical Defenses Against Pathogens (We…
Chapter 15 Lecture 4
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Nonphagocytic Killing
Phagocytosis involves killing of the pathogen once it has been ingested (once inside the phagocyte. But we can kill without phagocytosis.
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and tumors (neoplasms)
NK Cells can differentiate normal body cells because they have membrane proteins similar to the NK cells
Natural killer comes from the fact that NK cells are programmed to kill other cells unless they receive an inhibitory signal
Killing by neutrophils
Can destroy microbes without phagocytosis but phagocytosis is more common and they do in several ways
Enzymes in the cytoplasmic membrane add electrons to oxygen creating a superoxide radical and then another enzyme gets added into the mix to make hypochlorite (the active ingredient in bleach) and they kill nearby invaders
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Generate extracellular fibers called neutrophil extracellular traps (NETs) that bind to and kill bacteria