Please enable JavaScript.
Coggle requires JavaScript to display documents.
factors controlling erythropoiesis (hormonal factors (1.erythropoietin…
factors controlling erythropoiesis
hormonal factors
1.erythropoietin
glycoprotein
85% frm kidneys
15 % frm liver
acts on stem cells
promotes erythroid series
decrease cell cycle length
facilitates maturation of normoblasts
increases Hgb synth
stim early release of immature
erythocytes into circulation
2.androgens
stim erythropoietin production
directly stim erythropoiesis
3.eostrogen
inhibits erythropoiesis by
inhibiting erythropoietin prdctn
decr the response of stem cells to erythropoietin
decr hepatic synth of globulin
4.thyroxin,growth hormone,cortisol
stim erythropoiesis
5.interleukins
1,3,6,11
act mainly on stem cell to convert them to
progenitor cells
dietary factors
vitamins
vit B12, folic acid, vit C
necessary for the maturation of rbc precursors
as they promote DNA synthesis
vit C helps in the absorption of iron
proteins
essential for the synth of globulin
minerals
iron, cobalt, copper (forms part of vitB12
necessary for iron transfer
from storage sites (bone marrow ,liver & spleen
other factors
intrinsic factor
secretesd from
oxyntic cells of the stomach
helps in absorp of vit B 12
envronmental factor
hypoxia due to any cause
incr erythropoiesis by
incr erythropoietin prdn
drugs & chemicals
Vasoconstrictor agents like catecholamines, nucleotides like cAMP, NAD, NADP,
products of RBC destruction (hemolysates) & cobalt salts
stimulates erythropoiesis