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PCDC4 (increase tumorigesis), AR inhibiton (AKT (c-myc), Foxo3a (AP-1),…
PCDC4
increase tumorigesis
AR inhibiton
AKT
c-myc
Foxo3a
AP-1
PTEN (growth inhibitor)
AMPK
mTOR (survival)
Cox-2
PGE2
ERK1/2
G(1) phase
foxo3a
iNOS
PKC B
inhibit
D5 D4
EGF and bFGF
G(1)-S transition regulatory proteins
cyclin E
cyclin D1
cdk4
c-myc
(cdk)-2
mir 21
ROS
Nrf2
oxidotive stress
cell proliferaiton
DNA binding activity of E2F-1 and phosphorylation of retinoblastoma protein
HFD
nfkb
fidarestat
keap1
nrf 2 dna bindig activity
FGF and PDGF
induce
suppress
increase
increase
inhibit
increase
activate
prevent
activate
decrease
increase
increase
decrease
increase
inhibit
activate
synthesis
synthesis
down regulate
activate
egf
increase
decrease
increase
inhibit
help to adopt
accumilating cells in
inhibit
induce
activate
down regulation decreaed