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Acute kidney injury and Chronic Renal Failure, Kidney
Disease108321110…
Acute kidney injury and Chronic Renal Failure, Kidney Disease108321110
陳美嬌
RIFLE Classification for Staging
Acute Kidney Injury Network
Kidney Disease:
Improving Global Outcome
classification of AKI
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腎小管內阻塞
結晶沈積：尿酸，草酸，藥物。(methotrexate, acyclovir, triamterene, sulfonamides)
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腎小管
續腎前性腎衰竭，腎毒性物質 (aminoglycosides, radiocontrast agents, heavy metals)，肌蛋白，紅血球蛋白
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prerenal
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Efforts to restore adequate perfusion should be fully effective in restoring normal renal function within 1 to 2 days.
Postrenal
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If only one kidney is affected, remaining kidney will
increase to
maintain fluid and electrolyte balance.
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obstruction continues over several days or weeks, irreversible damage to the kidney will result
Acute tubular necrosis
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Acute tubular necrosis
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In the elderly, about 30% of ischemic cases are due to sepsis and another third are due to surgical interventions.
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Prolonged prerenal kidney injury, perioperative and postoperative hypotension, hemorrhage, gastrointestinal drainage, and preoperative cardiac complications
ATN-Nephrotoxic agent
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underlying kidney insufficiency, age > 70, volume depletion, repeated exposures to contrast media in a short time, and coexisting HF or DM
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Aminoglycosides, NSAIDs, amphotericin B, cisplatin, and tetracyclin
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Renal Functions and Structure
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內分泌 EPO, Renin, 1,25 Dihydroxy VitaminD
CKD
Renal Sodium Regulation
RAAS
Renin
Angiotensin
Aldosterone
System
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Potassium Regulation
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Neoplasms
Nephrotic syndrome
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Congenital Abnormalities
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