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Peroxisomal carnitine acetyl transferase is required for elaboration of…

- - - - PTH2 is required for turgor generation necessary for appressorium-mediated penetration
        
        Acetyl CoA from fatty acid b-oxidation could , be processed via the glyoxylate cycle and gluconeogenesis to yield precursors to glycerol biosynthesis, which is necessary for turgor generation
      - PTH2 is involved in the supply of acetate units for melanin biosynthesis via the dihydroxynaphthalene pathway
        
        Pth2 activity very likely contributes to melanin biosynthesis, CAT is not essential for turgor generation in appressoria
      - PTH2 required for cell wall generation and growth of penetration hyphae.
        
        peroxisomal fatty acid b–oxidation is vital for facilitating appressoriummediated infection in M. grisea
        
        Pth2 acts to make acetyl CoA available to the glyoxylate cycle which feeds through reactions of the gluconeogenesis pathway to support glucan and chitin biosynthesis
    - - highlights the dependence of foliar plant pathogens on lipid metabolism for supporting initial growth and development on the leaf surface
      - The absence of external nutrients during spore germination, which is essential to promote appressorium development by M. grisea
        
        lipid mobilization, peroxisomal fatty acid b-oxidation and generation of a pool of acetyl CoA are likely to be vital to allow this fungal pathogen to enter its host.
        
        a study of the anthracnose fungus Colletotrichum lagenarium, peroxisomal biogenesis was shown to be necessary for appressorium function
        
        deletion of the PEX6 peroxin encoding prevents peroxisome biogenesis and renders M. grisea completely non-pathogenic, lack the Woronin bodies where the peroxisomal bodies required for septal occlusion in fungi
        
        studies also shown in other fungi like Stagonospora nodorum , brassica pathogen Leptosphaeria maculans, Candida albicans and Blumeria graminis
- - - - ue to a requirement for peroxisomal acetyl-CoA
      - substrate for dihydroxynaphthalene melanin biosynthesis
- - - - conidiogenesis was reduced
      - spores germinated normally
        and developed appressoria
    - - nonabraded leaves of either rice or barley seedlings inoculated with Dpth2 mutant
      - small disease lesions
        
        abraded leaf
        sections inoculated with the Dpth2 mutant
    - - affect rice cuticle penetration and formation of penetration
        hyphae
    - - retain the capacity for production of polarized penetration pegs
      - able to breach yielding surface
      - reduced in their ability to elaborate penetration