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Neuropathic pain (Types of pain (Neuropathic Pain (Trigeminal Neuralgia…
Neuropathic pain
Types of pain
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Cancer-Related Pain
infiltration of organs
tumor compression
treatments that damage tissue such as radiation therapy or chemotherapy
sympathetic nervous system activation and behavioral changes
Neuropathic Pain
tissue injury
occur in the peripheral or central nerves.
constant aching sensations
burning or shocklike pain in the affected area
Allodynia is common
GABAergic interneurons are significantly depleted
Trigeminal Neuralgia
common in women than in men
frequently in middle-aged or older individuals
lesions or tumors of the brainstem
Chronic vessel compression
interruption and alteration in nerve signaling
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Processes of pain
transmission
A -alpha fiber
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thermal, mechanical stimuli
fast traveling, 5-10m/sec
C fiber
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polymodal stimuli(thermal, mechanical,chemical)
slow traveling, 0.6-2m/sec
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modulation
endorphin
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polypeptides (α-, β-, and γ-endorphin)
opioid receptors
mu (μ)
analgesia
sedation
respiratory depression
pupil constriction
nausea/vomitting
constipation
urine retention
pruritus
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