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Cell progress, Growth factors (Get binds (RAS +GTP (Raf (MEK (ERK +2…
Cell progress
Growth factors
Get binds
RAS
+GTP
Raf
MEK
ERK
+2 phosphates
Cycling D
+Cdk4
Cdk4
RB
+Phosphate
E2F
Cyclin E
P27
Cyclin D
P27 (Blocks progression)
P13 kinase
+Atp-ADP
Pip2
Pip3
Akt
+2phosphates
FOXO
Blocks FOXO
Bim
(pro-apoptosis)
Bad (pro-apoptosis)
Cyclin D
Cdk4
RB + phosphate
E2F
Blocks P27
Mtorg + PDK1
TSC
mTorc1
Blocks mTorc1
Translation
Apoptosis
Apoptasome
Caspase 9 + Apaf1
Cytochrome c
Bak + Bax
(Mitochondria)
Bcl2
Bllocks apoptosis
by grabbing Bax
DNA damage
ATM
Chk2
P52
PUMA +NOXA
(Pro-apoptosis)
Blocks Bax
P21
Cdk2/cyclinE