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Rheumatic Fever (Rx (Bed rest until CRP normal for 2wks, Benpen 0.6-1.2mg…
Rheumatic Fever
Rx
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Add oral pred if: CCF, cardiomegaly, 3rd degree block
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Pathophysiology
Ab cross-reactivity following S. pyogenes infection → T2 hypersensitivity reaction (molecular mimicry).
Abs cross-react w/ myosin, muscle glycogen and SM cells
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Dx: revised Jones Criteria
Evidence of GAS infection plus:
2 major criteria, or
1 major + 2 minor
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