Please enable JavaScript.

Coggle requires JavaScript to display documents.

Immune-mediated Skin Diseases (allergic dermititis (atopic dermatitis…

- - - - not fully understood
      - immunologic dysfunction
        
        type 1 hypersensitivity rxn
        
        express cells with strong IgE receptors
        
        basophils
        
        mast cells
        
        histamine release
        
        strong reaction against innocuous environmental allergens
        
        predominance of T-helpler 2 cells
        
        IL-4
        
        B cells secrete IgE
        
        IL-5
        
        activates eosinophils
        
        IL-31
        
        pruritus and inflammation
        
        signals that induce conversion of IgG to IgE
        
        itching damages keratinocytes, exasperbating immune response
        
        Langerhans cells (review this)
      - skin barrier dysfunction
        
        filaggrin normal fxn
        
        provide moisture
        
        balance pH
        
        protect against UV
        
        ceramides normal fxn
        
        deficiency in ceramides
        
        lipo-barrier compromised
      - environmental factors
  - - - types 1,3,4 hypersensitivity rxns
        
        only type 4 is cell mediated
        
        1,3 is antibody mediated
      - not well understod
      - IgE mediated
    - - food elimination trial: 8-10w
      - food challenge 2w
      - skin and serum tests are not reliable
  - - - itch
      - flea and flea dirt/feces
      - Positive intradermal test
      - response to flea control
    - - Isoxazoline
      - must eliminate every single flea
      - glucocorticoids temporary
  - - - face
      - ears/otitis
      - feet
      - axilla
      - plantar metacarpal
      - abdomen/groin/perianal
      - cubital flexor
      - neck
      - lichenitification
      - chronic inflammation
      - hyperpigmentation
      - secondary infections
        
        staphylococcus bactera
        
        neutrophils
        
        yeast
    - - food allergy
      - sarcoptic mange
      - flea bite allergy
      - scabies
    - - pruritis
        
        itchiness is only persistent symptom
        
        licking
        
        scratching
        
        chewing
        
        biting
        
        rubbing
        
        rolling
      - skin lesions
      - usually develop signs between 1-3y
      - year round or seasonal
        
        if year round, rule out food allergen
    - - try only if client requests
      - only 60% effective in treatment development against specific allergen
  - - - allergen specific immunotherapy
    - - novel diet
      - hydrolyzed diet
    - - glucocorticoids
      - anti-histamines
      - essential fatty acids
      - cyclosporine
      - oclacitinib
      - monoclonal antobody against IL-31 (Cytopoint!)