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Non-Alcoholic Fatty Liver Disease results from (Genetic Connection in…
Non-Alcoholic Fatty Liver Disease results from
Hormonal alteration
Adipose Derived hormones: Leptin Is elevated (leptin resistance)
Overnutrition/altered reward/motivation center and receptors in Nucleus Accumbens.
Genetic Connection in certain genes
Patatin-like phopholipase domain containing
increases risk/severity,
Neurocan
Cell adhesion molecules (hepatic steatosis)
Glucokinase regulatory protein
inhibiter in glucokinase
increase ALT, Hepatic steatosis
Protein phosphatase I regulatory subunit
Hepatic steatosis
causing a family history of liver disease, obesity, cardiovascular disease, diabetes
Inadequate Nutrition
High Fructose/High soda intake
leads to bad gut microbiome
bacteria gain systemic circulation via gut epithelial tight junctions
treated with antibiotics
High saturated fat, low fiber, carbohydrate rich diets
leading to clinical manifestations like obesity, hyperlipidemia, diabetes, and cardiovascular disease, hypertension, and an elevated BMI
Insulin Resistance
reduced hepatic glycogen storage
increased glucooncogenesis
increased adipocyte lipolysis
high circulating free fatty acids
results in increased hepatic lipid accumulation and LDL secretion.
Lipotoxicity: further impairs insuilin, oxidative damage, promotes inflammation/fibrosis
Diagnosis
Blood Testing
Thorough health/alcohol/family history
Liver biopsy
Ultrasound/CT/MRI
Treatment
Weight loss
minimize/cease alcohol consumption
Glycemic Control
metformin and insulin sensitizing agents
Pharmacology Intervention
Cancer, variceal, and regular screening