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Carbonhydrate (Glucose metabolism (Gluconeogenesis (syn glucose from non…

- - - - Glucokinase
        (liver)
        
        Insulin induces (regulation)
        Max speed @ high [GLU] — High Km
        not inhibit by G6P
      - Hexokinase
        (muscle, brain, adi)
        
        Not regulated by Insulin
        max speed @ normal blood GLU (low Km)
        allostrerically inhibit by G6P
    - - Alloryerically regulated by
        
        +: ATP, citrate
        
        -: ADP, AMP
      - Glycolysis stimulate
    - - Liver only
        glucagon activate
  - - - synthesis of nucleic acid (DNA, RNA)
        
        formation of other nucleotide (ATP, ADP, AMP)
    - - FA synthesis
        
        maintainable of Redding substrates in RBC
        
        liver: drug metabolism
    - - High:
        
        liver, cortex, adipose tissue adrenal ,
        lactating mammary gland
        —> synthesis of FA (increase NADPH demand)
      - Low:
        
        skeletal muscle (limit NADPH demand)
  - - - Glucogenic precursor — CORI CYCLE
    - - @ high [gu]: disposal glu
        
        @ low [glu]: release glu
        
        for rapid demand of E
      - Liver = blood hemeptasis
        muscle = instant E
- - - - GLUT-4 -- Glu into cell --> from glycogen
      - promote glycogenesis
  - - - pancreas release Glucagen
        
        breakdown glycogen to glucose
      - adrenal gland: Glucocorticoid
        
        increase Gly synthesis
  - - - lower the better
- - - - intestine cell
        
        GLUT-2 (mucosa our & liver uptake)
        
        liver
        
        GLU
        
        glycogen storage
        
        use as E
        
        send out to circulation
        
        GALA
        
        Trap, glucose metabolism
        
        FRU
        
        Trap, glycolysis
- - - - RBC --> blood brain barrier
        
        deficiency: genetic disorder, cause Brian GLU deficiency (decrease transport protein)
        
        cognitive, behaviour, movement disorder.
    - - chronic: glycosylation of protein (cell membrane disorder)
        organ & brain damage.