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Cancer (Hallmarks (Sustaining proliferative signaling, Evading growth…
Cancer
Hallmarks
Sustaining proliferative signaling
Evading growth supressors
Resisting cell death
Inducing angiogenesis
Activating invasion and metastasis
Avoiding immune destruction
Enabling replicative immortality
External factors
Alcohol
Smoking
Diet
Chemicals
UV light
Pathways
Rb pathway
RTK/Ras/PI3K pathway
PI3K/Akt/mTOR pathway
P53 pathway
Genes involved
Proto-oncogenes
Gain of function
Tumor supressor genes
Loss of function
Metastasis
Tissue/vessel invasion
Move through the curculation
leave the vessel
Establish new colonie at distant site