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Enlarged Kidneys (Examination (Significant Negatives (Unilateral…

- - - - HTN
        Pallor
    - - AV fistula (or scar)
        Tunnelled dialysis lines (or scar)
        Tenchkhoff catheter (or scar)
    - - Cushingoid
      - Skin tumours: AKs, SCC, BCC and MM
      - Gingival hypertrophy: ciclosporin
  - - - Nephrectomy scar
      - Rutherford Morrison scar
      - Tenchkhoff catheter (or scar)
    - - Palpable Kidney
        
        Flank mass
        
        Can get above it
        
        Ballotable
        
        Moves inferiorly w/ respiration
        
        Resonant PN
      - Hepatomegaly
      - Renal Transplant
- - - - 50% chance of transmission
      - 10% are de novo mutations
- - - - U+E: ↓eGFR, electrolyte disturbance
      - Bone profile: ↓Ca, ↑ PO4, ↑PTH
      - FBC: ↓Hb 2O to ESRF
    - - Abdo US
        
        Confirm renal enlargement
        
        Cysts
        
        Hydronephrosis
        
        Masses
        
        Liver enlargement
      - CT/MRI
        
        MRA: Berry aneurysms
        
        CT abdo: esp. if RCC suspected
    - - Genetic studies to look for mutation in
        PKD1 gene on Chr 16: 85%
        PKD2 gene on Chr 4: 15%
      - Family screen