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Basics of BIOINFORMATICS (DRUG DISCOVERY (Virtual ligands library…
Basics of BIOINFORMATICS
Unit I - Scope of Bioinformatics
Elementary commands and Protocols, ftp, telnet, http
Open access bibliographic
resources
nucleotide databanks
DDBJ
EMBL
Genbank, NCBI
protein databanks
sequence databanks
SWISSPROT
TrEMBL
PIR
structural databases
SCOP
PDB
CATH
DRUG DISCOVERY
Virtual ligands library preparation
optimization of ligand
validation
docking studies
target identification
Industrial application of CADD
SEQUENCING ALIGNMENT AND DYNAMIC PROGRAMMING
Algorithms issues in database search
sequence database search
Dynamic
programming
Smith-Waterman algorithm
Needleman-Wunch algorithm
-FASTA and BLAST
Protein motifs and
domain prediction
Gene Expression database
Derived Databases Protein-Protein interaction database.
Unit V - MOLECULAR MODELING AND DRUG DISCOVERY
abinition protein structural modeling
simulations
Minimum free energy method
threading
Basic concepts of Homology
Unit IV - COMPUTATIONAL GENOMICS AND PROTEOMICS
Understanding DNA microarrays and protein arrays
Gene and protein prediction strategies, phylogenetic analysis
Comparative genomics and Proteomics
promoter prediction in E.coli, and in
eukaryotes