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Influenza A (Characteristic of virus HPAI H5N1 (Virulence factor…
Influenza A
Characteristic of virus HPAI H5N1
Virulence factor
Mesogenic
Lentogenic
Velogenic
Surface antigen HA & NA (H5 &H7 are considered highly pathogenic)
Segmented genome
Mutating through antigenic drift into highly pathogenic varieties
Sample and Diagnostic Assay to confirm HPAI H5N1
Agent Detection
Virus isolation
Antigen detection
RT- PCR
Serological Method
AGID
HI
ELISA
Type Immunity
Humoral Immunity
IgM ( First infection)
IgA ( Mucosal Immunity)
Cell-mediated Immunity
Macrophage
MHC Class I (CD8 Tcell)
Cytotoxic cell
Vaccination against HPAI H5N1 in layers
Advantage
Able to induce mucosal immunity
Using recombinant live vector vaccine ( Strong response)
Enable differentiate infected & vaccinated animal because vaccine not induce antibodies against nucleoprotein or matrix
Disadvantage
Replicate poorly
Given day old may interfere maternal immunity