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POLYMYOSITIS (T cell mediated, muscle atrophy more common), skin…
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FEATURES
General
fatigue, malaise, weight loss
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proximal, symmetrical muscle weakness & autoimmune muscle breakdown
CK in 1000s
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Treatment
- corticosteroids
- MTX/azathioprine
- ciclosporin
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think: GCA
GIANT CELL ARTHIRITS
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can lead to:
carotid bruits
absent pulses (neck, arm)
thoracic aorta aneurysm/dissection
stroke
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DX: 3 of
- age >50
- new headache
- temporal tenderness/decreased pulsation
- ESR>50
- abnormal artery biopsy showing necrosis
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:pen:antisynthetase syndrome
related to DM & PM
antibodies against enzymes involved in protein synthesis
can go into respiratory arrest - will be weak beforehand
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