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A 23 year old male patient demonstrating severe face and arm muscle spasms…

- - - - effects inhibitory neurotransmitter
        
        Causes unregulated control/activity of the motor system.
        
        Results in spasm
      - Does not effect/ remain in neuromuscular junction
        
        Does not cause flaccid paralysis
        
        only effects inhibitory neurotransmitter
    - - New tattoos are usually covered in plastic.
        
        Perfect environment for Clostridium tetani to germinate
- - - - Needles from tattoo parlor were infected with Clostridum tatani bacteria
        
        Needle pierced through epidermis which contains no blood vessels
        
        Entered dermal layer which contain vessels
        
        Bacteria germinated due to anaerobic conditions
        
        Caused bacteria to germinate and produce tetanus toxin
      - Lymphatic system
        
        Tetanus toxin transferred to Nervous system via lymphatic system
        
        Muscular system
        
        Neuromuscular Junction
        
        Acetylcholine
        
        Receptors on sarcolemma
        
        Action potential
        
        2 more items...
        
        depolarization of post synaptic membrane
        
        Neurotrasmitter
        
        Motor neuron
        
        synaptic cleft
        
        Sarcolemma
    - - Action potential
        
        Release of neurotrasnmitter
        
        Acetylcholine for NMJ.
        
        Activation of Voltage gated channels
        
        Action potential
        
        neurotrasmitter
        
        via exytosis
- - - - Releases Ca+ into the Axon terminal of motor neuron
      - Increase of calcium causes exocytosis
        
        Exocytosis of vesicles containing Acetylcholine
        
        Acetylcholine diffuses down synaptic cleft to receptors on sarcolemma
        
        Receptors activate receptor gated gates for Sodium and potassium.
        
        Causes depolarization of membrane potential
        
        Membrane potential is -70mv
        
        If depolarization reaches threshold, action potential occurs down entire sarcolemma
        
        Causes calcium release from sarcoplasmic reticulumn
        
        1 more item...
    - - Threshold reached
        
        depolarization occurs
        
        Voltage gated sodium channels open
        
        Re-polarization occurs
        
        Na+ Channels close, K+ channels open
        
        K+ Leaves, making membrane potential closer to resting state
        
        Hyperpolorization
        
        More K+ leaves until the sodium potassium pump helps
        
        Helps restore membrane potential to -70mv
- - - - Causes continuous AP down sarcolemma and continuous muscle contractions
        
        Symptoms include lockjaw, Muscle spasms, and arched back
  - - - lethal effects
      - Causes tachycardia or bradycardia
        
        Can cause myocardial necrosis
    - - Lethal effects