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Anaphylaxis (Pathophysiology :star: (Type 1 - IgE mediated drug…
Anaphylaxis
Pathophysiology :star:
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- IgE antibodies formed - B cells
- IgE attachment to mast cell cell surface receptor
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- Allergen reacts with specific IgE antibodies on mast cells
- Cell degranulation releasing pro inflammatory mediators
- Histamine causes increased vascular permeability (capillary leakage), vasodilation, hypotension,
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Definition
severe, life threatening hypersensitivity reaction
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