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Acromegaly Current Treatments (Surgery (complications (damage to healthy…
Acromegaly Current Treatments
Medication
monthly somatostatin analogue/somatostatin receptor agonist injections
octreotide
first synthesised in 1979, now oral trials are underway
lanreotide
prolonged release formulations to increase dose intervals
pasireotide
approved in 2003, better tumour reduction and hormonal control
dopamine/dopamine recpetor agonists
bromocriptine
discovered in 1965 and quick release approved in 2009
cabergoline
pegvisomant
genetically engineered, recombinant GH-receptor antagonist
improves insulin homeostasis more
Surgery
can completely cure or may need further medication or radiotherapy
endoscopic
transsphenoidal
complications
damage to healthy parts of pituitary
CSF leakage
meningitis (rare)
Radiotherapy
stereotactic radiotherapy
high dose precise beam of radiation- usually takes one session with a headframe to prevent movement
linear accelerator (linac) machine or gamma knife machine- when developed it was x rays from electrodes and probes
conventional radiotherapy*
less precise beam of radiation, can damage surrounding tissue- takes many doses over 4-6 weeks