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SLE (Examination (Extras (Eyes: keratoconjunctivitis sicca, Lungs
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SLE
Examination
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Hands
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Jacoud’s arthropathy
- Mimics RA
- Due to tendon contractures
- Reducible on extension
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Extras
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Lungs
- Pleural rub
- Pleural effusion
- Fibrosis
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Renal
- HTN
- Dipstick for nephrotic syndrome
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Viva
Ix
Urine dip
GN: proteinuria, haematuria
Bloods
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Abs
- ANA: 100%
- dsDNA: 60% sensitive but very specific
- Anti-cardiolipin and lupus anticoagulant
Disease Activity
- ↑ ESR
↑ CRP suggests infection
- ↓ C3, C4
- ↑ dsDNA titre
Hx
- Systemic: fever, wt. loss, fatigue
- Photosensitivity rashes
- Arthralgia
Features
- Multisystem inflammatory disease characterised by a T3 hypersensitivity reaction against circulating immune complexes.
- ↑ in Afro-Caribbeans and Asians
Mx
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Severe Disease
AIHA, nephritis, pericarditis, CNS disease
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MDT: GP, rheumatologist in specialist SLE clinics