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Drug Interactions (Types (Pharmacokinetic (Metabolism (Enzyme Inhibitors …

- - - - Mainly IV drugs being mixed together
        E.g. calcium + sodium bicarbonate → precipitation
  - - - Tetracyclines and quinolones w/ Ca, Fe, Al
        Drugs chelate the metals and are not absorbed
    - - Warfarin + some NSAIDs
    - - Enzyme Inhibitors
        
        P450
        
        XO: allopurinol
        
        Dopa decarboxylase: carbidopa
        
        Acetaldehyde dehydrogenase: disulfiram,
        metronidazole
      - Enzyme Inducers
    - - Diuretics → ↓ Li clearance
      - Loop diuretics: ↑ aminoglycoside ototoxicity
  - - - Via ↓ K+
    - - Abx kill GI microflora that make Vit K
- - - - Enzyme inhibitors
        EtOH
        Simvastatin
        NSAIDs
        Dipyridamole
        Amiodarone
    - - Enzyme inducers