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Pharmacokinetics (Key Concepts (Clearance (Volume of plasma cleared of a…
Pharmacokinetics
Key Concepts
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Half-life
Time taken for drug concentration to decline to half its original value.
Depends on volume of distribution and clearance
Volume of Distribution
Volume into which a drug appears to distribute.
High for lipid-soluble drugs
Low for water soluble drugs
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Zero Order Kinetics
Clearance of drug not always proportional to plasma concentration.
Saturation of metabolism → constant rate of elimination regardless of plasma levels.
E.g. phenytoin, salicylates, ethanol
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