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Adverse Drug Reactions (Classification (Long-Term ADR (Dependence,…
Adverse Drug Reactions
Classification
Type A
Common, predictable reactions
Dose-related (but may occur @ therapeutic doses)
Consequence of known pharmacology of the drug
Type B
Rare, idiosyncratic reactions
Usually not dose-related
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Long-Term ADR
Dependence, addiction
Withdrawal
- Opiates
- Benzos
- Corticosteroids
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Determinants
Drug
- Pharmocodynamics
- Phamacokinetics
- Dose
- Formulation
- Route of administration
- Rate of aminophylline
Patient
- Age
- Organ dysfunction
- Genetic predisposition
- Co-morbidities
Renal: digoxin, aminoglycosides
Hepatic: warfarin, opiates
Allergies
Type 1: anaphylaxis
Penicillins, contrast media
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