Please enable JavaScript.
Coggle requires JavaScript to display documents.
patient diagnosed with neuromuscular junction (NORMAL FUNCTION OF MUSCULAR…
patient diagnosed with neuromuscular junction
(direct) tetanus toxin affects the interaction between the nerve & muscle that it stimulates specifically at neuromuscular junction
(direct) tetanus toxin amplifies the chemical signal from the nerve to muscle which causes the muscle spasms
(indirect) failed to get vaccinated to avoid this disease, did not go to a clean tattoo parlor and check to make sure a clean needle was being used
the paralysis induced by the toxin is due to blockade of neurotransmitter release
NORMAL FUNCTION OF MUSCULAR SYSTEM- is movement, but it also helps stabilize our joints, maintain our posture and generate heat
process of excitation-contraction coupling. 1.action potential generated along sarcomere to t-tubules
action potential triggers Ca2+ release
Ca+ binds to toponin,blocking action of tropomyosin release
contractions via cross-bridge formation ATP hydrolysis
removal of ca+2 by active transport
tropomyosin blockage restored, contraction ends
temporal summation- one person=one neuron rapidly firing presynaptic neuron that causes ESPs that are close in time & add together (temporal = time) summation brings axons initial segment to threshold & ap fires
NORMAL FUNCTION OF NERVOUS SYSTEM- The central nervous system CNS is responsible for integrating sensory information and responding accordingly. It consists of two main components: The spinal cord serves as a conduit for signals between the brain and the rest of the body
spatial summation- if more than one presynaptic neuron fires at the same time, EPSPs are operated at different locations on neuron , two EPSPs at the same time from different locations add together (spatial =location) summation brings the axons initial segment to threshold and AP fires
nervous system-tetanus produces a toxin in brain leading to stiffness in muscles & interferes with nerves that control muscle movement
structural classifications of nerons unipolar neuarons have short single process laving the cell body bipolar neurons- one axon - one dendrite multipolar nuerons- many extensions from cell body sensory nuerons collect info from recepetors integrating nerons process info and predict right response motor nuerons send directions for right response
the toxin in this bacterium affects the neuromuscular junction a couple ways
toxin is anaroebic bacillus clostridium- binds to nervous system and is transported to spinal cord, spastic paralysis induced by toxin due to blockade of nuerotransmitters to release from spinal inhibitory interneurons
Difference Between Inhibitory and Excitatory
Inhibitory synapses decrease the likelihood of the firing action potential of a cell while excitatory synapses increase its likelihood.
Excitatory synapses polarize neurotransmitters in the postsynaptic membrane while inhibitory synapses depolarize them
Excitatory synapses stimulate neurotransmitters while inhibitory synapses inhibit them
This bacterium produces a toxin that affects the brain and nervous system, leading to stiffness in the muscles called lockjaw
muscular system- the neurotoxin interferes with nerves that control muscle movement muscle spasms can even cause death
upstream causes
downstream causes
BACKGROUND
anatomy
physiology
