Please enable JavaScript.
Coggle requires JavaScript to display documents.
Male infected with Clostridium Tetani (background anatomy (Excitation…
Male infected with Clostridium Tetani
It is essentially blocking the the inhibitory neurotransmitters
this causes disinhibition of lower motor neurons, which activates voluntary muscle movements
**note to self
, has the opposite effect of botox on the body
resulting in muscle spasms
the patient failed to ensure that the needle that was being used for his tattoo was clean and sanitary
the patient did not vaccinate for tetanus (Clostridium tetani)
Downstream:
Muscular
painful muscle contraction, mostly in jaw and neck muscles "lockjaw"
Nervous
effecting the performance of neurotransmitters and inhibitory impulses
uncontrollable muscle contractions or even seizures
has the possibility of effecting the autonomic NS
could lead to other organ systems not working correctly
could ultimately lead to death
Respiratory
Lung blockage, blood clot in major artery
muscle spasms can cause issues with your breathing
ultimately lead to death
Lymphatic
makes the blood toxic
lead to other organ systems having issues
can ultimately lead to death
Skeletal
uncontrollable muscle spasms can lead to broken bones
background anatomy
Respiratory
gas exchange throughout the body
Muscular
provides the body with movement
Skeletal
provides the framework of the body
Nervous
sending and collecting information, sensory, integration, and motor functions
neuron
axon
carries impulses away from the cell
axon hillock
where axons leave the cell
axon terminals
end of the axon containing synaptic vesicles
cell body
location of nucleus & most of the organelles are found
dendrites
receives incoming signals and conveys them toward the cell body
Excitation-Contraction Coupling
Cells
muscle fiber
Neurotransmitters
motor neurons
connects the muscle fibers at the neuromuscular junction
communication between nerves and muscles happens through neurotransmitter
Ion Channels
chemically-gated sodium channel
chemically-gated calcium channel
Ions
releasing of calcium in the sarcoplasmic reticulum when the nearby sarcolemma is depolarized
sodium, allows action potential to travel across the sarcolemma because of v-g Na channels
K, will leave the cell to hyper polarize the membrane
Summation
additive effect of multiple electrical impulses on a neuromuscular junction between nerve and muscle cells
collect the information to generate the proper response
temporal
one sending multiple messages, close in time
spatial
more than one message coming from different locations
Clostridium tetani on the neuromuscular junction
binds at the presynaptic terminals, then transported by motor neurons to the spinal chord
then transferred to inhibitory presynaptic terminals surrounding those motor neurons
causes inactive inhibitory neurotransmission that allows for controlled muscle movements
causes the excitatory nerves to over produce resulting in muscle spasms
Excitatory vs. Inhibitory postsynaptic potentials
Excitatory (EPSP)
open channels the DEPOLARIZE the membrane
sodium gated channels
Inhibitory (IPSP)
open channels that HYPERPOLARIZE the membrane
potassium and chloride gated channels
