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Miscellaneous Gastrointestinal Drugs (Biologics (Infliximab: Remicade…
Miscellaneous Gastrointestinal Drugs
Hyoscine butylbromide
Buscopan
Antimuscarinic
Antispasmodic
Anti-AChM SEs
Dry mouth
Palpitations
CI Myasthenia gravis :red_cross:
Mebeverine
Peppermint oil
Antispasmodic
Loperamide
Opioid receptor agonist
Doesn’t cross BBB so no central
effects.
SE Abdo cramps
CI
Infective diarrhoea
Colitis
Caution in hepatic
impairment :red_cross:
Sulfasalazine
Mesalazine
5-Aminosalicylate
Unknown MOA
Sulfasalazine has ↑ SEs
blood dyscrasias
hepatitis
rash, urticaria
oligospermia
pulmonary fibrosis
Caution in renal or hepatic impairment
Monitor FBC :red_flag:
Budesonide
Used to induce remission in ileal Crohn’s
Steroid
More potent cf. prednisolone
High 1st pass metabolism to ↓
systemic effects.
Biologics
Infliximab: Remicade
Chimeric anti-TNF mAb
Etanercept: Enbrel
P75 TNFR-Fc fusion protein
Adalimumab: Humira
Human anti-TNF mAb
SE
Severe infections
TB
Allergic reactions
CCF
CNS demyelination
Screen for TB before use
Parenteral admin
Give w/ hydrocortisone to ↓
allergic SEs