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Patient with severe face and muscle spasms (Anatomy (Organ Systems…
Patient with severe face and muscle spasms
Causes
Direct Cause
Patient has Tetanus
causes constant release of neurotransmitters in the neuromuscular junction.
Indirect Cause
New Tattoo
Used a dirty needle
Tetanospasmin toxin got into his bloodstream
Effects
Organ systems
Nervous System
blocks inhibitory interneuron from preventing constant firing
constant release of neurotransmitters
Skeletal System
convulsions
lock jaw
broken bones
Muscular System
receives neurotransmitters to contract constantley
seizures and spasms
hard to breath
Anatomy
Organ Systems
Nervous System
Brain
Spinal cord
Peripheral Nerves
Muscular System
Muscles
Tendons
Skeletal System
Bones
Joints
Cartilage
Structural Classification of a Neuron
Unipolar
one extension off the cell body
Bipolar
two extensions off the cell body
Multipolar
multiple extensions off the cell body
Excitation Contraction Coupling
Neuromuscular Junction
Cell
Neuron
Muscle Fiber
Sarcolemma
Channels
chemically-gated Na+ channel
voltage-gated Na+ channel
Neurotransmitter
acetylcholine
Ions
Na+
Action Potential/ Ca2+ release
Channels
voltage-gated Na+ channel
voltage-gated K+ channel
voltage-gated Ca2+ channel
Cell
muscle fiber
sarcolemma
sarcoplasmic reticulum
T-tubules
Actin
troponin
tropomyosin
Ions
Na+
K+
Ca2+
Cross Bridge Cycle
Cell
Muscle Fiber
Actin
myosin binding site
Myosin
myosin head
Chemical
ATP
ADP +Pi
Summation
neurons membrane potential
excitatory postsynaptic potentials (EPSP)
Na+
inhibitory postsynaptic potentials (ISPS)
K+,Cl-
Clostridium tetani
tetanospasmin toxin
Physiology
Clostridium tetani
tetanospasmin toxin
makes the neuron constantly release neurotransmitters
making the muscles constantly contract until is spasms
Summation
Adds the sum of the membrane potential
ESPS
Na+ depolarizes the membrane
ISPS
K+, and Cl- hyperpolarize the membrane
Threshold is met at a -55mv membrane potential and depolarization begins
Organ Systems
Nervous System
Detects and processes sensory information
Activates bodily response
Muscular System
Enables movement
Helps maintain bodily temperature
Skeletal System
Supports the body and enables movement
Functional Classification of a Neuron
Sensory neuron
transmit impulses from a receptor to the central nervous system
Interneuron
process incoming sensory information and predicts the proper motor output
Motor Neuron
carry impulses away from central nervous system to the effector
Excitation Contraction Coupling
Neuromuscular Junction
Neuron releases acetylcholine
Acetylcholine attaches to chemically-gated Na+ channel of the muscle fiber
Muscle fibers sarcolemma begins to depolarize and opens the voltage-gated Na+ channels.
Action Potential/ Ca2+ release
depolarized sarcolemma open the voltage-gated K+ channels and begins action potential
action potential travels to the T-tubules, opening the voltage-gated Ca2+ channels of the sarcoplasmic reticulum
Ca2+ binds to traponin, changing its shape and moving tropomyosin, revealing the myosin binding site
Cross Bridge Cycle
Myosin head attaches to the actins myosin binding site using ADP+Pi
Myosin head pulls actin past myosin using the power stroke
ATP detaches the myosin head from actin
ATP changes to ADP+Pi through hydrolysis and cocks the myosin head back into prestrike position