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Heparin (Side effects (Thrombocytopenia
Immune-mediated
Develops ~6d…
Heparin
Side effects
Thrombocytopenia
- Immune-mediated
- Develops ~6d after initiation (2-3% of people with UH)
- → thrombosis
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Indications
Treatment
- VTE
- ACS
- Acute arterial obstruction
Prophylaxis
- VTE
- Coagulation in extra-corporeal circuits
LMWH or UH
LMWH has longer t½ and response is more predictable so no monitoring needed
Less risk of HIT and osteoporosis
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UH has rapid onset and short t½
Useful when rapid control over effects needed (e.g. risk of bleeding)
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MOA
Co-factor for ATIII: inhibits factors 2, 10, 11 and 12.
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Contraindications
- Bleeding disorders
- Plats <60
- Previous HIT
- PU
- Cerebral haemorrhage
- Severe HTN
- Neurosurgery