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Lipid Lowering Therapy (Rosuvastatin
Atorvastatin
Simvastatin
…
Lipid Lowering Therapy
-
-
Orlistat
-
-
CI
Cholestasis Interactions
Warfarin
- Difficulty controlling INR
SE
- GI upset
- steatorrhoea
- abdo distension
↓ absorption of fat-sol
drugs and vitamins
-
Bezafibrate
Gemfibrozil
Fibrates
Stimulate lipoprotein lipase →
- ↓TG: 36%
- ↓LDL: 8%
- ↑HDL: 10%
-
CI
Gallbladder disease
PBC
↓ albumin (esp. nephrotic syndrome)
R L P B
Interactions ↑ risk of myositis c¯ statins
↑s fx of anti-diabetics
W+
-
Statin Indications
- Any known CVD
- DM (age >40)
- 10yr CVD risk ≥20%
Aim: TC ≤4mM