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Miscellaneous Respiratory Drugs (Theophylline MR Aminophylline (↑d levels…
Miscellaneous Respiratory Drugs
Theophylline MR
Aminophylline
MOA
Methylxanthines
PDE inhibitors
↑cAMP → bronchodilatation
SE
Nausea
Arrhythmias
Seizures
↓ K
↑d levels
CCBs
CyP inhibitors
Aminophylline is IV form
give IVI slowly
Too fast → VT
monitor with ECG and
check plasma levels
CYP metabolism
↓d levels
EtOH
CyP inducers
smoking
Montelukast: Singulair
Zafirlukast
MOA Leukotriene receptor antagonist
Block cysteinyl leukotrienes
SE ? Churg-Strauss
Use NSAID and exercise-induced asthma
Roflumilast
PDE-4 inhibitor
SE GI
CI Sev immunological disease
Omalizumab
Humanised anti-IgE mAb
SC injection every 2-4wks
Used for severe asthma
Selective H1 R inverse agonists
aka H1 antagonists
Non-sedating
Certirizine
Des-/ Loratidine: Clarityn
Fexofenadine
Sedating
Chlorphenamine: Piriton
Mucolytic
Carbocysteine
SE GI bleed (rare)
CI Active peptic ulceration
Use: COPD
Dornase ALFA (DNase)
Use: CF